pone.0296925.g001.tif (473.84 kB)
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posted on 2024-01-19, 18:51 authored by Poliana Mendes Duarte, Bruno César de Vasconcelos Gurgel, Tamires Szeremeske Miranda, Juliana Sardenberg, Tongjun Gu, Ikramuddin AukhilIPA analysis of the canonical pathways related to the DEGs altered in tissues with periodontitis compared with tissues with periodontal health in non-diabetic patients. (A) The top ten dysregulated canonical signaling pathways are presented in descending order of statistical significance of −log(P-values). (B) The canonical pathways that were predicted to be modulated in the non-diabetic patients, as defined by a −log(P-value) >2 and Z-score <−1.3 (inhibited). (C) The number of upregulated and downregulated DEGs involved in each of the representative canonical pathways.
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whole transcriptome sequencingtype 2 diabetespreliminary findings indicatedifferentially expressed genebiological mechanisms underlyingdistinctive transcriptomic changesdegs confirmed changessignaling pathways associatedsectional study evaluatedingenuity pathway analysisdiv >< pipa also predictedsectional studythree degsipa predictedfunctional pathwaysakt pathwaysdistinctive genesuniquely identifiedtrna splicingptpn2 ptpn13 protein expressionpik3r2 phagosome formationperiodontal healthitga4 il1rn gingival biopsiesfour hundreddhcr24 cholesterol biosynthesiscardiac βcalcrl 6r
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