pone.0296340.g002.tif (351.43 kB)
Extrapolation of transition probabilities for patients treated with aboBoNT-A plus BSC and BSC alone over a lifetime horizon.
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posted on 2024-02-01, 18:46 authored by Peter Moore, Natalya Danchenko, Diana Weidlich, Alejandra Rodarte TijerinaAbbreviations: aboBoNT-A, abobotulinumtoxinA; BSC, best supportive care. Top: Patients treated with aboBoNT-A plus BSC. Bottom: Patients treated with BSC alone. Note: Logarithmic transformation of the time variable in both arms.
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xlink "> spasticitypublished pivotal trialsprobabilistic sensitivity analysisincurable chronic conditiondetermine regression probabilitiesunweighted regression analysessensitivity analyses confirm721 per quality000 per qualityshort time horizoneconomic model basedeffectiveness ratios includecommonly acceptable costadjusted life yearscenario analysesrelated qualitylifetime horizonmodel parametersmarkov modeltreatment costsstudy objectivestopping ruleresults remainingrestricted mobilitypay thresholdmuscle stiffnessincremental costfunctional outcomeseffectiveness ratioearly treatmentcapture changesbase caseacute event
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