pgen.1009113.g003.tif (1.13 MB)
Expression profile of tumor immune responses genes, estimated neoantigens and TCR repertoire diversity.
figure
posted on 2021-01-21, 18:25 authored by Shotaro Sakimura, Satoshi Nagayama, Mitsuko Fukunaga, Qingjiang Hu, Akihiro Kitagawa, Yuta Kobayashi, Takanori Hasegawa, Miwa Noda, Yuta Kouyama, Dai Shimizu, Tomoko Saito, Atsushi Niida, Yusuke Tsuruda, Hajime Otsu, Yoshihiro Matsumoto, Hiroki Uchida, Takaaki Masuda, Keishi Sugimachi, Shin Sasaki, Kazutaka Yamada, Kazuki Takahashi, Hideki Innan, Yutaka Suzuki, Hiromi Nakamura, Yasushi Totoki, Shinichi Mizuno, Masanobu Ohshima, Tatsuhiro Shibata, Koshi MimoriA) The top row shows the estimated neoantigen (NAG) level (min500HLAMer, min50HLAMer and non-synonymous mutation), and red indicates the high level of NAG. The second row represents TCR repertoire diversity (#clonotype and #molecular identification group; #MIG), and red indicates heterogeneity intensity. B) Association between cytolytic activity (CYT) and tumor immune response-related factors, such as min500HLAMer, TCR repertoire clonotype, CD8, CD4 and IFNG in primary (upper row) and in metastasis (lower row). In addition, CYT activity and expression of TBX21, CD19, CD86, LTA, HLA-B, LAG3 and A2AR were compared.
