pone.0262173.g007.tif (672.05 kB)
Expression of FADS1 and FADS2 is associated with genotype at rs174537.
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posted on 2022-01-20, 18:26 authored by L. Madison Kirk, Charlotte Mae K. Waits, Alexander C. Bashore, Beverly Dosso, Allison K. Meyers, Antonio C. Renaldo, Thomas J. DePalma, Kelli N. Simms, Nathaniel Hauser, Chia-Chi Chuang Key, Charles E. McCall, John S. Parks, Susan Sergeant, Carl D. Langefeld, Aleksander Skardal, Elaheh RahbarEffect of diet and genotype at rs174537 were analyzed using a linear regression model, where GG at rs174537 was considered the referent genotype. Data are reported as mean with SEM. No significant differences were observed in the expression of (A) FADS1 or (B) FADS2 between LA-exposed and human serum albumin (HSA)-control hepatic culture models. When analyzed by genotype alone, (C) FADS1 expression was significantly higher in GT constructs, and lowest in TT constructs. (D) A similar trend was seen in FADS2 expression. Interestingly FADS1 and FADS2 expression levels were highest in GT donors.
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specifically linoleic acidgenetic variants nearfatty acid desaturasediv >< pdimensional hepatic constructdimensional culture modelsde novo lipogenesisfatty acid metabolismsignificantly reduced fads1reproducibly displayed allelemodern western dietincluding lipid esterificationdriving human diseasespecific metabolic activityslowest metabolic conversionhuman pufa metabolismlipid metabolismsubsequent metabolismminor alleleincluding obesityhuman pufahuman populationsfads1 activitycardiovascular disease>) displayedvivo tt rs174537 results supportrelevant genepoorly replicatemechanistic explorationinflammatory metabolitesinflammatory mediatorsinflammatory diseasesindividuals homozygoushepatocytes derivedhaplotype blockenriched mediae .,dietary omegadiet interactionscurrent twocholesterol efflux3d hydrogels
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