Exercise performance after 6 weeks of treadmill training.

(A) Timelines of treadmill training, endurance (Endur.) and sprint exercise tests. Ten-month-old Nprc MKO and control male mice were trained on a treadmill at a speed of 60% of their maximal running speed for six weeks. (B, C) Mice were subjected to (B) sprint exercise test and (C) endurance exercise test at baseline (Sedentary) and after treadmill training (Exercised) to determine their maximal running speed and exhausted running time, respectively. (D) The body weight of each group of mice at baseline and after treadmill training. Two-way ANOVA, ** p < 0.01; **** p < 0.0001; and p>0.05, no statistical significance.