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Evolution of action potential with time.

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posted on 2024-01-05, 18:32 authored by Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand Deo

A. Simulated AP of hiPSC-CM model for various percentages of IKr block (0%, 50% and 100%). Action potential duration prolonged with increasing IKr conductance block. B. Simulated AP of rabbit Purkinje cell (RPC) model for various percentages of IKr block (0%, 50% and 100%). Action potential duration prolonged with increasing IKr conductance block. 100% IKr blockade produced DAD. C. Simulated action potential of a rabbit ventricular myocyte (RVM) model for various percentages of IKr block (0%, 50%, and 100%). D. Simulated action potential of a human Purkinje cell (HPC) model for various percentages of IKr block (0%, 50%, and 100%). E. Simulated action potential of a human ventricular myocyte (HVM) model for various percentages of IKr block (0%, 50%, and 100%).

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    long qt syndromeexperimental findings suggestcell derived cardiomyocytesamino acid changeheterozygous missense mutationherg current compareddiv >< pherg current blockades428p ), respectivelypurkinje cells exhibithek cells producedgo related geneherg currentherg ),partial blockadewild typeventricular myocytestransiently transfectedposition 428outer loopold infantold girlkcnh2 human etherhigher susceptibilityheterologous expressiongenetic screeningfirst mutationcomputer simulationsarrhythmogenic substratearrhythmogenic potentialsaction potentials>, resulting

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