ppat.1009878.s007.tiff (7.48 MB)
Evaluation of cell death in human PBMC cultures treated with live SARS-CoV2.
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posted on 2021-09-02, 17:25 authored by Martina Severa, Roberta A. Diotti, Marilena P. Etna, Fabiana Rizzo, Stefano Fiore, Daniela Ricci, Marco Iannetta, Alessandro Sinigaglia, Alessandra Lodi, Nicasio Mancini, Elena Criscuolo, Massimo Clementi, Massimo Andreoni, Stefano Balducci, Luisa Barzon, Paola Stefanelli, Nicola Clementi, Eliana M. Coccia(TIFF)
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plasmacytoid dendritic cellsearly events resultingproductive viral replicationinhibiting viral replicationex vivo elevated inflammatory cytokineimmune cells occurringdiv >< pcytokine storm observedifn producing cellsifn response accompaniedpbmc enhances anti>, asymptomatic sarshigh serum typeimmune cellsviral responseviral ifnhigh levelsviral statevitro via inflammatory phenotypeinflammatory cytokinesifn secretedifn levelifn axisvigorous tlr7tissue damagestimulated genesshed lightorgan failurelow frequencyl1 markerkey roleinduced typeimpaired typeiii ifnshospitalized patientsearly interactiondependent productiondependent mechanismchemokine levelsassociated multi
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