Evaluation of IFN-γ or GrB/IL-10 ratios in LST+/Scar+, LST+/Scar-, LST-/Scar+ and LST-/Scar- individuals.

IFN-γ/IL-10 (a) and GrB/IL-10 (b) ratios were calculated using the levels of IL-10, IFN γ and GrB measured by ELISA in culture supernatants of PBMCs from the donors. The ratios’ values are shown for LST+/Scar+, LST+/Scar-, LST-/Scar+ and LST-/Scar- groups. The box represents the 25^th and 75^th percentiles. The median is represented by a solid horizontal line. The whiskers of the box show the 1^st percentile to the 99^th percentile. Statistically significant differences between the median of stimulated and non-stimulated cultures were assessed by the non-parametric median test. Results of the median test are shown. Statistical significance was assigned to a value of p<0,05.