Estimates of drug delivery and comparisons to rifampicin and clofazimine distribution data in experimental granulomas.

Dimensionless concentration (lines), f, of rifampicin (A; RIF) and clofazimine (B; CFZ) as a function of dimensionless granuloma radius, ξ, for increasing values of dimensionless granuloma size (the modulus α₀) in comparison to experimental data from mouse TB granulomas [17] (dots). The mean squared error (MSE, see Eq S44) between the theoretical and experimental results for rifampicin and clofazimine are 0.012 and 0.010, respectively (see S2 Table for all raw data, predicted data, and MSE values).