pone.0259643.g006.tif (1.28 MB)
Enzyme activity of CYP.
figure
posted on 2021-11-09, 18:26 authored by Nina Zemanová, Kateřina Lněničková, Markéta Vavrečková, Eva Anzenbacherová, Pavel Anzenbacher, Iveta Zapletalová, Petra Hermanová, Tomáš Hudcovic, Hana Kozáková, Lenka JourováCYP enzyme activity was measured in pooled hepatic microsomal samples of SPF and GF mice (control group and time 2h, 6h and 24h after application of metronidazole). Data represent the mean ± SD from pentuiplicates measured in pooled microsomal samples of 4 SPF groups of mice and 4 GF groups of mice. Group of SPF mice before metronidazole application (0) was used as a control. (dicl–diclofenac, diaz–diazepam).
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selected cytochromes p450remain mostly elusiverecent studies indicategut microbiota mayaltered gut microbiotaxlink "> microbiomegut microbiome modulatesgut microbiome affectssignificant metabolic organshown lower leveldrug metabolizing enzymesgut microbiomesignificant interactionparent drugbiotransformation enzymesvice versaresults hencereported earlierpharmacotherapy interventionsmutual relationshipmurine plasmamolecular mechanismsimmense potentialhigher levelshepatic cypscyps ).control specific30 %)
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