pone.0250340.g001.tif (1.03 MB)
Efficient ablation of DCs in PLP TCR Tg. CD11c-DTA SJL mice.
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posted on 2021-04-23, 17:35 authored by Thaiphi Luu, Julie F. Cheung, Jennifer Baccon, Hanspeter Waldner(A) Representative frequencies and (B) mean numbers ± SEM of cDCs (CD11chi MHC II+) and pDCs (CD11clo B220+ CD11b-) in the thymus (A) and spleen (A, B) of PLP TCR Tg. CD11c-DTA SJL mice (n = 4) or PLP TCR Tg. DTA SJL control mice (n = 3), as determined by flow cytometry, are shown. Numbers in dot plots represent percentages of live cells. Data shown are from four independent experiments. * p = 0.03 (Student’s t test).
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self-reactive CD 4PLP-specific CD 4myelin-specific T cellsCD 11cExperimental Autoimmune Encephalomy...TCRmyelin proteolipid proteinMSPLP T cell receptorpro-inflammatory T cell responsesSJL mice constitutivelyPLP-specific T cellsCNS myelin antigensself-reactive T cellsDCEAET cell responsesT cellsInflammatory CD 4dendritic cells results
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