Effects of chronic GIPR antagonism on body weight, food intake, and fasting blood glucose and insulin.

(A) GIPA-1 and GIPA-2 chronic studies schematic. (B-K) Effects of chronic administration of GIPA-1 and GIPA-2 on body weight (B and C), food intake (D and E), fasting plasma glucose (F and G), fasting plasma insulin (H and I) and HOMA-IR (J and K) in DIO mice. Group sizes are n = 10, and data are represented as mean ± SEM. Statistical analysis was calculated using two-way ANOVA with Tukey’s post-hoc test and one-way ANOVA for AUC with Dunnett’s post-hoc test. *: p< 0.05, **: p < 0.01, ***: p < 0.001, ****: p<0.0001 compared to vehicle.