Effects of betaine on diuresis [μl/min/g k.w.], HR [bpm] and MABP [mmHg] in anesthetized Spontaneously Hypertensive rats and Wistar Kyoto normotensive rats.

The priming dose of betaine was 0.5 mmol/kg b.w., 2.8 mmol/kg b.w. or 5.0 mmol/kg b.w. (5 min in a bolus), followed by continuous infusion at a rate of 0.5 mmol/kg b.w., 2.8 mmol/kg b.w. or 5.0 mmol/kg b.w./ 55min. Values are means ± S.E.M. ^#—p<0.05 post-treatment vs. baseline, *- p<0.05 betaine vs. vehicle within the same rat strain, ANOVA for repeated measures followed by a t-test for independent variables with Bonferroni’s correction.