pone.0202182.g003.tif (353.27 kB)

Effects of PF-05231023 during water restriction.

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posted on 2018-08-14, 17:32 authored by Tod Turner, Xian Chen, Matthew Zahner, Alan Opsahl, George DeMarco, Magalie Boucher, Bryan Goodwin, Mylène Perreault

Water intake (A), urine output (B), urine electrolyte concentrations (C) and urine electrolyte excretion (D) were measured in rats that were water restricted for 12 hours (n = 10). Water restriction was initiated immediately after dosing. Data presented as mean ± SEM. One way ANOVA followed by Tukey’s multiple comparison test was utilized to determine significance (S1 Table). Significant difference indicated as *p<0.05 versus vehicle control animals.