Effects of PA024 on body weight, heart rate, and blood pressure in vivo.
figureposted on 2017-08-11, 17:27 authored by Dai Suzuki, Akiko Saito-Hakoda, Ryo Ito, Kyoko Shimizu, Rehana Parvin, Hiroki Shimada, Erika Noro, Susumu Suzuki, Ikuma Fujiwara, Hiroyuki Kagechika, William E. Rainey, Shigeo Kure, Sadayoshi Ito, Atsushi Yokoyama, Akira Sugawara
Nine-week-old Tsukuba hypertensive mice (THM; hRN8-12 x hAG2-5), which present excessive Ang II production and chronic hypertension, were randomized for injection with either vehicle (corn oil) or PA024 (10 mg/kg/day) intraperitoneally 3 times a week for 7 weeks. Body weight (A), heart rate (HR) (B), systolic blood pressure (SBP) (C) and diastolic blood pressure (DBP) (D) were monitored once a week throughout the treatment. Data represent mean ± S.E.M. (n = 5). **P<0.01, *P<0.05, n.s: not significant vs. control mice at each week-old.
retinoid X receptoraldosterone secretionaldosterone synthase geneHSDdiastolic blood pressurepa 024Ad 5 elementsRXR pan-agonist PA 024CYP 11B transcription21ANURR 1 expressionPA 024-mediated CYP 11B transcription suppressionAd 5 elementpan-agonist PA 024CYP 11B mRNA expressionsteroidogenic enzyme groupPA 024-mediated suppressionPPAR γ agonist pioglitazoneNURR 1 overexpressionHuman CYP 11B promoterPA 024 treatmentNGFIBadrenocortical H 295R cellsCYP 11B promoter activityPA 024Tsukuba hypertensive miceRXR agonist PA 024CYP 11B expressiontranscription factors NURR 1blood pressureNBREAng II-induced mRNA expression