pone.0245235.s005.tif (545.04 kB)
Effects of Naturido on the time spent in the target quadrant and in other quadrants in a Morris water maze test with senescence-accelerated model mice (SAMP8 mice).
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posted on 2021-01-27, 18:23 authored by Shinichi Ishiguro, Tetsuro Shinada, Zhou Wu, Mayumi Karimazawa, Michimasa Uchidate, Eiji Nishimura, Yoko Yasuno, Makiko Ebata, Piyamas Sillapakong, Hiromi Ishiguro, Nobuyoshi Ebata, Junjun Ni, Muzhou Jiang, Masanobu Goryo, Keishi Otsu, Hidemitsu Harada, Koichi Suzuki(A) The times spent in the target quadrant and in the other quadrants were compared on day 9, mice with normal ageing (SAMR1 mice) (n = 7), Senescence-accelerated mouse (SAMP8) mice (n = 12), SAMP8 + donepezil HCl (1250 μg/kg/day) mice (n = 11), SAMP8 + Naturido (2.5 μg/kg/day) mice (n = 14), SAMP8 + Naturido (25 μg/kg/day) mice (n = 7). (B) Representative images of the circular swimming path captured by video. Left, senescence-accelerated mice (SAMP8 mice); right, SAMP8 + Naturido (25 μg/kg/day) mice. All values are expressed as means ± SEMs. *P <0.05 vs the SAMP8 group (Dunnett test using JMP10.0.0).
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