ppat.1011954.s005.tiff (237.51 kB)
Effects of BNRF1-KO on gene expression of LCLs.
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posted on 2024-02-01, 18:30 authored by Ken Sagou, Yoshitaka Sato, Yusuke Okuno, Takahiro Watanabe, Tomoki Inagaki, Yashiro Motooka, Shinya Toyokuni, Takayuki Murata, Hitoshi Kiyoi, Hiroshi Kimura(A) RNA-seq volcano plot analysis of differentially expressed genes (DEGs) in LCLs-WT compared with LCLs-dBNRF1. Upregulated and downregulated DEGs are mapped as red and blue spots, respectively. (B and C) Gene ontology biological process enrichment analysis of DEGs that were upregulated (B) and downregulated (C) in LCLs-WT compared with LCLs-dBNRF1.
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reactive oxygen speciesmice xenograft modellytic replication contributesinducible protein 27conserved among gammapromotes cell proliferationlymphoblastoid cell linesseq analyses revealedlytic gene bnrf1div >< pcell deathfindings revealedwt resultedwt ).vivo vitro significantly decreasedseveral malignanciesprimary infectionlatent factorsimportant roleexcessive productionexamined whethercausally associatedcancer developmentbnrf1 elicitedbarr virusalso confirmed
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