Effects of Ac3IV treatment on islet cell turnover and expression of ductal cell markers in STZ-diabetic Ins1Cre^/+Rosa26-eYFP mice.

Parameters were assessed following 12 days twice-daily treatment with saline (0.9% NaCl) vehicle or Ac3IV (25 nmol/kg bw, i.p.) in STZ- diabetic Ins1Cre^/+Rosa26-eYFP transgenic mice. Beta- and alpha-cell proliferation (A,B) and apoptosis (C,D) were assessed by Ki67 or TUNEL co-staining with insulin/glucagon, respectively. CK-19 co-localisation with insulin in pancreatic ductal (E) and islet (F) cells. Values are mean ± SEM for n = 6 mice. *p<0.05, **p<0.01, ***p<0.001 compared to saline vehicle. ^Δp<0.05 and ^ΔΔp<0.01 compared to STZ-diabetic controls.