Effect of post-symptomatic therapeutic administration of anti-VP6 VHH on RVA shedding in feces.

Mean titer of virus shed (determined by ELISA) detected daily in pooled feces from mice receiving pre-symptomatic and post-symptomatic treatment comprising 200 μg of 2KD1 and the untreated control group. The arrow shows inoculation time (PID 0). Post-symptomatic administration of 2KD1 (200 μg) significantly reduced overall fecal shedding with respect to the untreated control group when AUC comparison was performed (ANOVA, p = 0.002). The thin horizontal line indicates the duration of VHH passive treatment. PID: Post Inoculation Day.