Effect of hypercholesterolemia on striatal dopamine level in Parkinsonian mice.
figureposted on 2017-02-07, 18:31 authored by Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Borah
Mice were sacrificed by decapitation on the seventh day following the first dose of MPTP. Striatal dopamine content was analyzed by HPLC-ECD system. Hypercholesterolemia exaggerates striatal dopamine depletion in Parkinsonian mice. The results are given as mean ± S.E.M. *p ≤ 0.05 as compared to control (CS) and #p ≤ 0.05 as compared to MPTP alone treated group (n = 6).
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hypercholesterolemiacause oxidative stressstriatal dopamine levelsAltered antioxidant homeostasismitochondrial functionsPDoxidative stress Hypercholesterolemiamidbrain dopaminergic neuronsdopaminergic neuronsnigrostriatal pathwaySNmitochondrial dysfunctionspotentiate dopaminergic neuron lossIIIMPTP modelMPTP mouse model