Effect of high-fat (HF) diet on the liver of c/d KO mice.

(A) Liver Oil-Red-O staining for lipid droplets. Analysis of plasma leptin levels (B), plasma triglyceride levels (C), and liver triglyceride content (D) in WT and c/d KO groups fed normal chow or a HF diet. Data are expressed as mean ± SEM (n = 5–7 mice/genotype/diet). *p<0.05 by Bonferroni post hoc analysis after intergroup differences were found by 1-way ANOVA. *p<0.05, **p<0.01, ****p<0.0001 by two-sample t-test.