Effect of LY379268 treatment on baroreflex sensitivity.

The HR and MAP response of LY379268-treated SHRs to intravenous injection of phenylephrine (21 μg/kg) (A and B) and sodium nitroprusside (50 μg/kg) (D and E) were recorded, respectively. The vertical dashed lines indicate the onset time of phenylephrine or sodium nitroprusside injection. LY379268-treated SHRs had better reflex bradycardia than sham control SHRs, but not reflex tachycardia. *P < 0.05, **P < 0.01, and ***P < 0.001 versus sham control; statistical evaluations were performed using unpaired t-test. The data in each group are mean ± SEM from four to five rats. HR, heart rate; MAP, mean arterial pressure.