Ecotin orthologs from pathogenic microbes inhibit all three MASP enzymes.
figureposted on 2019-12-20, 18:33 authored by Zoltán Attila Nagy, Dávid Szakács, Eszter Boros, Dávid Héja, Eszter Vígh, Noémi Sándor, Mihály Józsi, Gábor Oroszlán, József Dobó, Péter Gál, Gábor Pál
Affinities of the four ecotin orthologs as well as SGMI-2 and TFMI-3 toward MASP-1 (light grey bars), MASP-2 (black bars) and MASP-3 (dark grey bars) are shown as–log10(KI) (M) values. Asterisks (*) indicate that no inhibition could be detected.
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alternative pathway-related damageecotin orthologsalternative pathwaymicrobicidal activitiesfactor D activatorflow cytometry experimentspathway-specific ELISA testsalternative pathway-driven complement attackcomplement-unrelated antimicrobial activitylectin pathway inhibitorsprotectioncomplement activation routeMASPcell proliferation experimentsserine protease inhibitorantimicrobial drug targetserumcomplement lectin pathway