ppat.1008232.g001.tif (920.9 kB)

Ecotin orthologs from pathogenic microbes inhibit all three MASP enzymes.

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posted on 2019-12-20, 18:33 authored by Zoltán Attila Nagy, Dávid Szakács, Eszter Boros, Dávid Héja, Eszter Vígh, Noémi Sándor, Mihály Józsi, Gábor Oroszlán, József Dobó, Péter Gál, Gábor Pál

Affinities of the four ecotin orthologs as well as SGMI-2 and TFMI-3 toward MASP-1 (light grey bars), MASP-2 (black bars) and MASP-3 (dark grey bars) are shown as–log₁₀(K_I) (M) values. Asterisks (_*) indicate that no inhibition could be detected.

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Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum

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alternative pathway-related damage ecotin orthologs alternative pathway microbicidal activities factor D activator flow cytometry experiments pathway-specific ELISA tests alternative pathway-driven complement attack complement-unrelated antimicrobial activity lectin pathway inhibitors protection complement activation route MASP cell proliferation experiments serine protease inhibitor antimicrobial drug target serum complement lectin pathway

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