pntd.0011803.s001.tif (578.29 kB)
Differential gene expression in r-HAT cases vs controls.
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posted on 2023-12-06, 18:35 authored by Peter Nambala, Julius Mulindwa, Harry Noyes, Vincent Pius Alibu, Barbara Nerima, Joyce Namulondo, Oscar Nyangiri, Enock Matovu, Annette MacLeod, Janelisa Musaya(A) Sample to sample hierarchical clustering heatmap with complete linkage of cases vs controls. (B) Radial plot of the distribution and interception of DEGs in Stage1 and Stage 2 blood vs control blood. Grey color represents genes that were not significant; red represents genes enriched in stage 1 only; green represents genes enriched in stage 2 only; blue represents genes enriched in controls only; light blue genes in cases and control; pink represents genes enriched in both stage1 and controls; and yellow represents genes enriched in both stage 1 and stage 2 blood.
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significant differentially expressedfuture research whetherhuman transcriptome profilesgene expression profiles4 – 2lipid metabolism genes7 controls excluded28 healthy controlsr studio usingidentified biological pathwayshat case samplesstage 2 rgene enrichment analysisearly stage 1malawi stage 2stage 1transcriptomic profilescontrol samplesdownstream analysisdifferential analysis4519 genes1824 genes23 rrhodesiense p adjustedneutrophil activationmalawi varieslate stagesinnatedb algorithmsidentified transcriptsfunctional annotationdeseq2 packagedata addcurrent understandingclinical presentationcausative agentb age range
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