pone.0290493.s001.tif (1.08 MB)
Dietary cystine restriction is not causing significant damage in the intestine.
figure
posted on 2024-01-05, 18:37 authored by Judith C. W. de Jong, Kristel S. van Rooijen, Edwin C. A. Stigter, M. Can Gülersönmez, Marcel R. de Zoete, Janetta Top, Matthijs J. D. Baars, Yvonne Vercoulen, Folkert Kuipers, Saskia W. C. van Mil, Noortje IjssennaggerA) Body weight gain of the mice during the intervention (weight at d14 minus weight at d0 (in gram) (n = 8/group, mean ± SEM). B) Total crypt length (μm) of 15 colonic crypts per mouse (with the median per mouse). C, D) Gene expression of damage markers Ier3, Ripk3 and Birc5 in small intestine (C) and colon (D). (n = 8/group, mean ± SEM).
(TIF)
History
Usage metrics
Categories
Keywords
stem cell markersintestinal mucus layergut microbiome compositionbile acid conjugationapparent systemic effects88 million peoplelow cystine feedinglow cystine concentrationintermolecular cystine bridgeshigh fat dietlow cystine dietincreased epithelial proliferationgoblet cell numberslow dietary cystinediv >< ptherefore inherently lowproliferative capacity specificallyessential amino acidmice proliferative capacitycystine restrictionvegetarian dietproliferation markerki67 goblet cellsdietary intakewnt signalingwhole grainsvegetarian dietssufficient uptakeprotein synthesisplasma methioninelargely dependentfound earlierbarrier function2 weeks
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC