pone.0290493.g004.tif (584.61 kB)
Dietary cystine restriction increases Wnt signaling in small intestine.
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posted on 2024-01-05, 18:37 authored by Judith C. W. de Jong, Kristel S. van Rooijen, Edwin C. A. Stigter, M. Can Gülersönmez, Marcel R. de Zoete, Janetta Top, Matthijs J. D. Baars, Yvonne Vercoulen, Folkert Kuipers, Saskia W. C. van Mil, Noortje IjssennaggerA) Gene set enrichment analysis for a Wnt signaling signature reveals significant enrichment with low cys vs ctrl (NES = 1.37, FDR = 0.07). B) qPCR gene expression analysis of Wnt target genes (n = 8/group, mean ± SEM, multiple unpaired t-tests, **p<0.01). C) Heatmap of multiple enriched Wnt target or signature genes from the RNAseq data comparing low cys to normal cys (expressed as log fold change).
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stem cell markersintestinal mucus layergut microbiome compositionbile acid conjugationapparent systemic effects88 million peoplelow cystine feedinglow cystine concentrationintermolecular cystine bridgeshigh fat dietlow cystine dietincreased epithelial proliferationgoblet cell numberslow dietary cystinediv >< ptherefore inherently lowproliferative capacity specificallyessential amino acidmice proliferative capacitycystine restrictionvegetarian dietproliferation markerki67 goblet cellsdietary intakewnt signalingwhole grainsvegetarian dietssufficient uptakeprotein synthesisplasma methioninelargely dependentfound earlierbarrier function2 weeks
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