pone.0290493.g001.tif (512.34 kB)
Dietary cystine restriction does not affect metabolism into cystine breakdown products.
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posted on 2024-01-05, 18:37 authored by Judith C. W. de Jong, Kristel S. van Rooijen, Edwin C. A. Stigter, M. Can Gülersönmez, Marcel R. de Zoete, Janetta Top, Matthijs J. D. Baars, Yvonne Vercoulen, Folkert Kuipers, Saskia W. C. van Mil, Noortje IjssennaggerA) Plasma cysteine (reduced) (abbreviated as Cys (red)), methionine (Met), glutathione and taurine levels measured by metabolomics (n = 8/group, mean ± SEM). B) qPCR gene expression of enzymes converting methionine to cysteine (CTH) and cysteine to glutathione (GSS, GCLC, GCLM) normalized by normal cys (n = 8/group, mean ± SEM). C) Bile acid concentrations measured in bile (n = 5/normal cys; n = 4/low cys, mean ± SEM). D) Excreted bile acids per 24h (right), measured in feces (n = 8/group, mean ± SEM).
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stem cell markersintestinal mucus layergut microbiome compositionbile acid conjugationapparent systemic effects88 million peoplelow cystine feedinglow cystine concentrationintermolecular cystine bridgeshigh fat dietlow cystine dietincreased epithelial proliferationgoblet cell numberslow dietary cystinediv >< ptherefore inherently lowproliferative capacity specificallyessential amino acidmice proliferative capacitycystine restrictionvegetarian dietproliferation markerki67 goblet cellsdietary intakewnt signalingwhole grainsvegetarian dietssufficient uptakeprotein synthesisplasma methioninelargely dependentfound earlierbarrier function2 weeks
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