pone.0247901.g004.tif (396.45 kB)
Deletion of A2 reduced EAE-induced axonal degeneration.
figure
posted on 2021-03-18, 17:37 authored by Amritha A. Candadai, Fang Liu, Abdelrahman Y. Fouda, Moaddey Alfarhan, Chithra D. Palani, Zhimin Xu, Ruth B. Caldwell, S. Priya NarayananA-D) Confocal images of optic nerve sections from WT EAE mice demonstrate disorganized and damaged axons in the EAE optic nerves. Asterisks (*) indicate areas of axonal damage. E) Quantification of SMI 32 fluorescence intensity using ImageJ. Number of animals used: 8(WT Control);12 (WT EAE); 9 (A2-/- EAE); 7 (A2-/- Control). Representative images are presented. Data are presented as mean ± SEM. #p<0.01 WT EAE vs WT Con and A2-/- EAE vs WT EAE is non-significant. Scale bar 20 μm.
