pone.0287206.g006.tif (414.21 kB)
Delayed Afterdepolarization (DAD) activity window of the rabbit Purkinje cell model.
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posted on 2024-01-05, 18:32 authored by Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand DeoA. Intracellular calcium concentration within the junctional SR of rabbit Purkinje cell (RPC) model during action potential (AP) for various percentages of IKr block (0%, 50%, and 100%). 100% IKr blockade produced DAD. B. Intracellular calcium in the cytosol of the rabbit Purkinje cell (RPC) model for various percentages of IKr block (0%, 50%, and 100%). C. Simulated AP of rabbit Purkinje cell (RPC) model for 100% IKr block. D. Current tracing of the various ionic currents that underlie the RPC model AP for 100% IKr blockade within a DAD activity window. Within a DAD activity window, the sodium-potassium exchanger current (INCX) and the inward rectifying potassium current (IK1) do not get to zero at the resting phase of AP.
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long qt syndromeexperimental findings suggestcell derived cardiomyocytesamino acid changeheterozygous missense mutationherg current compareddiv >< pherg current blockades428p ), respectivelypurkinje cells exhibithek cells producedgo related geneherg currentherg ),partial blockadewild typeventricular myocytestransiently transfectedposition 428outer loopold infantold girlkcnh2 human etherhigher susceptibilityheterologous expressiongenetic screeningfirst mutationcomputer simulationsarrhythmogenic substratearrhythmogenic potentialsaction potentials>, resulting
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