Decay-accelerating factor (DAF) aggravates IAV infection in vivo.

A, B: Bodyweight loss (A) and mortality (B) of C57BL/6J WT or Daf^-/- mice infected with 1000 PFU of A/California/7/2009 (Cal) (Inf n = 8; mock n = 3 per group) C, D: Bodyweight loss (C) and mortality (D) of C57BL/6J WT or Daf^-/- mice infected with 1000 PFU of A/England/195/2009 (Eng) (Inf n = 9 per group; mock n = 5 and n = 4 for WT and Daf^-/- respectively). Results are expressed as mean±sd, statistical analysis detailed in materials and methods.