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Cumulative drug release.

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posted on 2021-09-30, 17:30 authored by Nikita Lomis, Susan Westfall, Dominique Shum-Tim, Satya Prakash

Cumulative drug release (mean ± SD %, n = 3) of MRN from AT1-HSA-MRN-NPs with starting MRN concentration of 0.8 mg/mL over predetermined time intervals of 0, 0.25, 0.5, 0.75, 1, 2, 4, 8, 18 and 24 hrs.

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    lacking target specificityexhibits low bioavailabilityexhibit superior targetingcovalent conjugation reaction9 ± 18 ± 2improves myocardial contractility4 ± 14 %, respectively2 ± 4overexpressing at1 receptorsh9c2 cells treateddrug delivery characteristicsdiv >< pcongestive heart failuretargeted cardiac uptakeheart failureh9c2 cellstargeted drugtargeted deliverymyocardial infarctioncardiac functionzeta potentialvs 44vivo vasodilatory effectssurface functionalizedsignificantly highernanoparticle sizeintracellular uptakehypertrophic conditionscumulative releaseangiotensin ii7 nm7 mv24 hrs

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