pone.0262657.g004.tif (130.86 kB)
Correlation between PRNT and competitive ELISA.
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posted on 2022-01-18, 18:30 authored by Adam V. Wisnewski, Jian Liu, Carolina Lucas, Jon Klein, Akiko Iwasaki, Linda Cantley, Louis Fazen, Julian Campillo Luna, Martin Slade, Carrie A. RedlichEach symbol (N = 32) represents the reciprocal IC50s from paired samples from the same subject tested in competitive ELISAs (Y-axis) and PRNT (X-axis). Note axes and trend line fitted to log scale.
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live viral cultureshighlights marked declinesfindings raise concernaccomplished using pairs42 vaccinated individualssoluble biotinylated ace2race2r inhibitory activitysurrogate neutralizing activityreceptor binding domainpost vaccine serumhelp assess responsesbooster vaccine dosesxlink "> testslongitudinal analyses precompetitive elisa basedxlink ">vaccine responsescompetitive elisaace2r interactionsvaccine receivedhost receptorwithout ),surrogate sarssub ><significant differencespublished studiesprior historypotential needmay wanegold standardfell substantiallyexcellent correlationevaluate nenable evaluationcentral roleadditional n>32 samples2 immunity0001 ).
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