pone.0259106.g001.tif (1.61 MB)
Conventional angioplasty balloon catheters coated with a novel, modified iopromide based matrix.
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posted on 2021-10-29, 17:31 authored by Ole Gemeinhardt, Beatrix Schnorr, Ulrich Speck, Bruno SchellerDrug dose: 6 μg Paclitaxel/mm2 balloon surface. Balloon size: 5.0 x 40 mm. (A) inflated, (B) partly inflated with three folds, and (C) folded.
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statistical significant differencespresent preclinical trialmay reduce medicocurrently marketed productscurrent study investigated2 – 310 ± 36 ± 1two overlapping dcbeconomic cost comparedconventional balloon catheters2 increased drug transferincreased drug concentration3 μg ptxdrug coated balloons6 μg ptxnovel dcb coateddrug transfer6 μgincreased ptxreproducibly coatedptx concentration5 μg2x3 μg1x6 μg1x3 μgresidual ptxvessel wallsingle balloonperipheral arteriesdifferent effectivenessballoons resulted178 ).
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