ppat.1009030.s005.tif (711.46 kB)
Concentration-dependent binding of human PGLYRP1 to B. burgdorferi.
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posted on 2020-11-11, 18:34 authored by Akash Gupta, Gunjan Arora, Connor E. Rosen, Zachary Kloos, Yongguo Cao, Jiri Cerny, Andaleeb Sajid, Dieuwertje Hoornstra, Maryna Golovchenko, Natalie Rudenko, Ulrike Munderloh, Joppe W. Hovius, Carmen J. Booth, Christine Jacobs-Wagner, Noah W. Palm, Aaron M. Ring, Erol FikrigSpirochetes from B. burgdorferi culture were incubated with increasing concentrations of (A) recombinant human PGLYRP1-His8, and (B) recombinant mouse PGLYRP1-His6, at concentrations 0.01 μg/mL, 0.1 μg/mL and 1 μg/ml. Representative results from one independent experiment are shown. Each data point represents an individual animal in the corresponding group. Data is expressed as the percentage of spirochetes that were shown to bind. The Y-axis represents relative cell counts calculated as percentage of the maximum events (Borrelia).
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exhibits borreliacidal activityPeptidoglycan Recognition Protein 1burgdorferi infectionspirochete Borrelia burgdorferiIFNburgdorferi sensu latosystems biology approachsecretome library screenDiverse host responses influenceCXCLyeast display screeningserum IgG levelsLyme borreliosis Lyme diseasePGLYRP 1yeast display library
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