pntd.0010159.g002.tif (691.36 kB)
Compounds inhibiting growth of the Sordariomycetes and the Pleosporaleans at 25 μM.
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posted on 2022-02-04, 18:36 authored by Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de SandePanel A, Madurella mycetomatis; B, Madurella tropicana; C, Madurella tropicana; D, Falciformispora senegalensis; and E, Medicopsis romeroi. 47, 42, 37, 26 and 7 compounds were able to inhibit the tested fungal isolates respectively. The horizontal black-lines in the figures shows the growth percentage at 20%. Compounds situated under the black-lines were able that inhibited more than 80% fungal growth and thus a growth below 20%.
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pandemic response boxminimal inhibitory concentrationsmedicinal chemistry optimisationfungal orders sordarialesaminoquinolone derivative tafenoquinemadurella tropicana madurella pseudomycetomatis galleria mellonella find novel drugsfalciformispora senegalensis div >< pseven inhibited growthpromising drug candidatesmadurella mycetomatis benzimidazole carbamates fenbendazoleeumycetoma promising candidatesmycetomatis vivo vitro novel antifungalstreat eumycetomasignificantly prolongmycetos ).medicopsis romeroilike moleculeslarvae survivalfour compoundsfive speciescure ratescompounds activealso serve26 compounds
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