pone.0262657.g001.tif (197.82 kB)
Competitive ELISA to detect antibodies that block SARS-CoV-2 spike-RBD binding to human ACE2r.
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posted on 2022-01-18, 18:30 authored by Adam V. Wisnewski, Jian Liu, Carolina Lucas, Jon Klein, Akiko Iwasaki, Linda Cantley, Louis Fazen, Julian Campillo Luna, Martin Slade, Carrie A. RedlichA surrogate assay for neutralizing capacity is depicted with plate bound RBD-murine IgG Fc and soluble ACE2r.
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live viral cultureshighlights marked declinesfindings raise concernaccomplished using pairs42 vaccinated individualssoluble biotinylated ace2race2r inhibitory activitysurrogate neutralizing activityreceptor binding domainpost vaccine serumhelp assess responsesbooster vaccine dosesxlink "> testslongitudinal analyses precompetitive elisa basedxlink ">vaccine responsescompetitive elisaace2r interactionsvaccine receivedhost receptorwithout ),surrogate sarssub ><significant differencespublished studiesprior historypotential needmay wanegold standardfell substantiallyexcellent correlationevaluate nenable evaluationcentral roleadditional n>32 samples2 immunity0001 ).
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