Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis - Fig 5

Comparative analysis of PD-1 (A), HLA-DR (B), CD39 (C) and CCR5 (D) on α4β7⁺and α4β7^-cells of healthy individuals and patients with UC. Frequencies of PD-1 (A), HLA-DR (B), CD39 (C) and CCR5 (D) α4β7⁺ and α4β7^- CD4⁺ T cells isolated from blood of healthy individuals (green), vedolizumab-naïve patients with ulcerative colitis (UC baseline, light blue) and patients with ulcerative colitis treated with vedolizumab (UC + VDZ, grey) Cryopreserved samples were thawed and directly stained with an α4-specific antibody (clone 7.2R) plus a β7-specific antibody (clone FIB504). Data from 9 healthy subjects, 8 vedolizumab-naïve patients with ulcerative colitis and 6 patients with ulcerative colitis treated with vedolizumab presented as means +/- standard deviation. ns ≥ 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, as calculated by Wilcoxon matched-pairs signed rank test. VDZ, vedolizumab; UC, ulcerative colitis; TCM, central memory T cells; TEM, effector memory T cells; TTM, transitional memory T cells; ns, not significant.