Comparison of the distribution of fractional Hamming distances between the generated and natural sequences for DHFR, P53 and MTOR.

Panels A, B and C. Distribution of fractional Hamming distances between random pairs of sequences within an ensemble shown as the fraction of pairs for which the hamming distance h_rand (y-axis) is greater or equal than value h (x-axis). Panels D, E and F. Distribution of fractional Hamming distances to the closest sequence within an ensemble for different models shown as the fraction of sequences for which the minimum hamming distance h_min(y-axis) is greater or equal than value h (x-axis). Panels G, H and I. Distribution of fractional Hamming distances to closest natural sequence for different models shown as the fraction of sequences for which the minimum hamming distance h_min to MSA (y-axis) is greater or equal than value h (x-axis).

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