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Comparison of fixed lens anharmonicity values.

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posted on 2021-09-14, 17:23 authored by Ariel M. Alperstein, Kathleen S. Molnar, Sidney S. Dicke, Kieran M. Farrell, Leah N. Makley, Martin T. Zanni, Usha P. Andley

Percent of locations versus anharmonicity values for juvenile human lens (yellow, top row), cataract human lens (purple, second row), three wild type mouse lenses combined (blue, third row), and three Cryab-R120G mutant mouse lenses (red, bottom row).

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    measure uv radiationdiv >< pdeveloping pharmacological treatmentscross peak frequencyalso widely distributedordered secondary structurelike secondary structurecross peak changesmutant mouse lensesrelated cataract diseaseprotein structural relevancediagonal peak frequenciesform amorphous aggregates>- r120g knockwt mouse lensesmouse lens modelhuman hereditary cataractsdimensional infrared spectroscopyhuman lensesdimensional infraredmouse modelporcine lensesocular lenslike fibrilsinduced changeshighly orderedhereditary cataracts>- r120gcrystallin aggregatesvitro tissues throughoutstudy ageneurodegenerative diseasesheterooligomeric complexgeneral agecryab chaperone activityarginine 120alzheimer ’aggregated proteins

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