Comparison of Genetic PDEA for gene dependency data sets between the Broad and Sanger Institutes.

To examine the reproducibility of Genetic PDEA, we compared data from pan-cancer CRISPR-Cas9 gene dependency data set (Sanger Institute) through the Genetic PDEA pipeline. We combined statistical tests using the harmonic mean p-value (HMP). When applying an HMP threshold of 0.05 and a false discovery rate threshold of 0.05, we see 96% and 90% agreement between the Genetic PDEA results from the DepMap and the Broad Institute.

(EPS)