Comparison of GPVI expression between control and stroke cohorts and GPVI-dimer as a function of total GPVI in control and stroke cohorts.

A) Total GPVI and B) GPVI-dimer are both significantly higher in the stroke population at admission compared to the control cohort (P <0.0001). P-values were calculated using an unpaired t-test and the error bars represent the mean MFI of each of the cohorts ± SD. C) Correlation between platelet surface total GPVI-dimer and GPVI-dimer. These data were calculated using Pearson correlation coefficient and the regression line is presented for each set of data. The control platelets show a narrow range of GPVI-dimer levels, which is negatively correlated to total GPVI (P <0.0001). In contrast, the surface GPVI-dimer of stroke patients’ platelets demonstrate strong positive correlation to the amount of total GPVI (P <0.0001) and in general have higher GPVI-dimer levels than the controls. MFI = mean fluorescence intensity.