pone.0263026.g006.tif (677.6 kB)
Comparative solubilization (%) of Rosuvastatin in pure form and developed βCD/PVP-co-poly (AMPS) nanogels in distilled water (highest solubility), phosphate buffer of pH 6.8 (high solubility) and HCl buffer of pH 1.2 (low solubility).
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posted on 2022-01-21, 18:54 authored by Hina Shoukat, Fahad Pervaiz, Mehran Khan, Sadia Rehman, Faizan Akram, Usman Abid, Sobia Noreen, Muhammad Nadeem, Rubina Qaiser, Rizwan Ahmad, Irshad FarooqComparative solubilization (%) of Rosuvastatin in pure form and developed βCD/PVP-co-poly (AMPS) nanogels in distilled water (highest solubility), phosphate buffer of pH 6.8 (high solubility) and HCl buffer of pH 1.2 (low solubility).
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resultant functional groupsradical polymerization methodmethylpropane sulphonic acidgood thermal stabilitydrug loading percentagedrug delivery carriersdiv >< pblending different amounts5 ± 3excellent physicochemical propertiesdrug release patterns8 ph parallelednontoxic nanogels mightcrosslinked hydrophilic nanogelsftir spectrum depictscrosslinker methylene bisacrylamidesize analysis depictsdeveloped nanogels revealedmethylene bisacrylamidedeveloped nanogelsrelease studiesmicromeritics propertiesgel analysiszeta sizeparticle sizehybrid nanogelsvivo various formulationsremarkable reductionpresent studyporous structurepoorly wateroral administrationmarketed brandsleading peaksimproved dissolutionefficient fabricationcapable approachblended constituentsbiological systems2 ph14 nm
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