Common somatic mutations were observed in four independent GBM datasets including CGGA, TCGA, CPTAC, and MAYO-PDX.

a) A Venn-diagram depicting the overlap and unique somatic mutations detected in the four GBM datasets. b) TMB box plots for the 10 commonly mutated genes in GBM datasets, compared to each gene’s wild-type samples. c) Somatic interactions are shown as co-occurrence or mutually exclusive events among the 10 commonly mutated genes in GBM.