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Clustering and cell type identification of cells in epididymal and inguinal adipose depots.

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posted on 2021-12-31, 18:43 authored by Blaine Harlan, Hui Gyu Park, Roman Spektor, Bethany Cummings, J. Thomas Brenna, Paul D. Soloway

Clustering and cell type identification of cells in epididymal and inguinal adipose depots.

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    vertical sleeve gastrectomyterm weight lossreceived sham surgeryprecede weight lossfatty acid desaturasedependent metabolic shiftcell atac sequencingtreat obesity resultingspecific cellular compositionchromatin accessibility patternscell chromatin accessibilitydiv >< pepididymal adipose depotsepididymal depotsspecific reductionattenuate obesityadipose playssubstantially reducedreduced accumulationobserved depotmechanisms underlyingmature adipocyteslipid profilinginsulin resistancehealth improvementsenergy homeostasiscrucial rolecardiometabolic pathologiesbeneficial effectsadipocytes induced

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