pgen.1010012.s005.tif (3.6 MB)
Clustering analysis illustrates the robustness of the RiboMethSeq data.
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posted on 2022-01-18, 18:42 authored by Jonathan Delhermite, Lionel Tafforeau, Sunny Sharma, Virginie Marchand, Ludivine Wacheul, Ruben Lattuca, Simon Desiderio, Yuri Motorin, Eric Bellefroid, Denis L. J. LafontaineAt each of the six developmental stages analyzed, four individual embryos were tested. Clustering of the RiboMethSeq analysis (here shown only for the 18S and 5.8S rRNA modifications; the same result was observed with 28S rRNA modifications) illustrates the remarkable robustness of our dataset. The staged embryos analyzed are depicted.
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six developmental stagesfunctional ribosomal subunitsevery living cellessential nanomachines responsiblediv >< pneural crest cellsncc survival causedindividual embryos indicatedearly developmental defectsrrna 2 ’-fbl knockdown leadsearly embryonic developmentxenopus laevis 18s rrna production2 ’-xenopus laevis rrna processingprotein productionneural platencc derivativesfibrillarin knockdowndeveloping embryos28s rrnax fbl validated orthogonallyusing ribomethseqthree positionsspecific positionsnew onesnccs ),methyltransferase fibrillarinmethylated positionsmassive p53including 10frog developmentefficient predependent apoptosiscraniofacial skeletoncraniofacial developmentcalled ribosomopathiesbox cbioinformatic screening>, confirming
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