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Clostridia are not depleted in infected IL-1β -/- mice.
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posted on 2024-01-18, 18:41 authored by Mor Zigdon, Jasmin Sawaed, Lilach Zelik, Dana Binyamin, Shira Ben-Simon, Nofar Asulin, Rachel Levin, Sonia Modilevsky, Maria Naama, Shahar Telpaz, Elad Rubin, Aya Awad, Wisal Sawaed, Sarina Harshuk-Shabso, Meital Nuriel-Ohayon, Mathumathi Krishnamohan, Michal Werbner, Omry Koren, Sebastian E. Winter, Ron N. Apte, Elena Voronov, Shai Bel(A) Absolute number of Clostridia OTUs in gut microbiota of Salmonella-infected mice as in Fig 3. (B) qPCR analysis of levels of the class Clostridia in uninfected mice housed and treated as indicated. Each dot represents a mouse. These data are representative of 1 experiment. *P < 0.05. Student’s t test. OTUs, operational taxonomic unit; RQ, relative quantity. Numerical values are in S1 Data. The underlying data for this figure can be found at GSE252071.
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sup >-/-reduced tissue damageoutcompete commensal microbesintracellular pathogens likeinactivator carboxypeptidase nfatty acid oxidationepithelial cell metabolismdiv >< pchain fatty acidswitching energy productionprocess via ilestablish gut colonizationacute gastrointestinal infectionmice lacking il1β induces expression1β productionexploits iluninfected patientstyphimurium triggerssalmonella remains unclearrecruit neutrophilsprevented depletionpatients sufferingintestinal defenseinterleukin 1βhealthy individualsfindings identifyexpression correlatescpn1 ).controlling mortality1β signaling1β ).1β (<
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