Fig 7.TIF (746.78 kB)
Chiral plasma-concentration time profiles for bupropion and hydroxybupropion.
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posted on 2016-03-11, 01:15 authored by Andrea E. Steuer, Corina Schmidhauser, Eva H. Tingelhoff, Yasmin Schmid, Anna Rickli, Thomas Kraemer, Matthias E. LiechtiPlasma-concentration time profiles for R- and S-bupropion (A) and R,R- and S,S-hydroxybupropion (B) after co-administration of placebo (black) or MDMA (white). Circles represent R- and R,R-stereoisomers. Triangles represent S- and S,S-stereoisomers. The data are expressed as mean and SEM (n = 16 participants). Differences between placebo and MDMA were not statistically significant.
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CYP 2D MDMA metabolismCYP 2D activityAUC 244- hydroxy -3-methoxymethamphetamineblood plasma samplesEM1 week placeboHMMAChiral Blood Plasma Pharmacokineticsplasma concentration-time curvehydroxybupropion stereoisomer pharmacokineticsCYP 2D functionDHMA 3- sulfateC maxCytochrome P 450 2 D 6 FunctionMDMA administration study24 hIIIMDHMA 4- sulfateCYP 2D genotypeCYP 2D demethylenation
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