ppat.1009784.s007.tif (238.86 kB)
Chemical inhibitors of NPC1 potently inhibited ASFV infection in primary alveolar macrophages.
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posted on 2022-01-26, 18:38 authored by Miguel Ángel Cuesta-Geijo, Isabel García-Dorival, Ana del Puerto, Jesús Urquiza, Inmaculada Galindo, Lucía Barrado-Gil, Fátima Lasala, Ana Cayuela, Carlos Oscar S. Sorzano, Carmen Gil, Rafael Delgado, Covadonga Alonso(A) Cytotoxicity assay at increasing concentrations of the compounds in macrophages. (B) ASFV replication in drug-treated and untreated ASFV infected cells analyzed by real-time PCR. Error bars indicate SD from three independent experiments. Statistically significant differences are indicated by asterisks (*p < 0.05).
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yet essential processinfectious cycle startsdynamin mediated endocytosisviral nucleic acidsmaller viral factoriesnpc1 ko cellsinternalized via clathrinarrested within endosomeslysosomal membrane proteinsinner viral membranecellular endosomal proteinsasfv proteins e248rmembrane fusion stependosomal proteins mightendosomal membraneendosomal proteinsviral proteinslimiting membranefusion stependosomal exitviral fusionviral coresviral adsorptionasfv proteinsvirion dissolvingupon decapsidationresults suggestph actsouter capsidnpc1 knocknew insightsmultilayer structurelate endosomeincoming virionshost cellfindings paveendocytic pathwayasfv infectivityasf virionalso observed
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