pone.0287206.g003.tif (241.3 kB)
Channel availability recordings for WT and co-transfected WT&S428P channels using standard triple-pulse protocol.
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posted on 2024-01-05, 18:32 authored by Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand DeoChannel availability recordings from a WT (A) and WT+S428P (B) using a standard triple-pulse protocol (top of figure). C. Plot of normalized current density versus voltage for WT and co-transfection of WT+S428P. WT and co-transfection of WT+S428P showed no significant difference in the mid inactivation values. WT: n = 18, WT+S428P: n = 8.
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long qt syndromeexperimental findings suggestcell derived cardiomyocytesamino acid changeheterozygous missense mutationherg current compareddiv >< pherg current blockades428p ), respectivelypurkinje cells exhibithek cells producedgo related geneherg currentherg ),partial blockadewild typeventricular myocytestransiently transfectedposition 428outer loopold infantold girlkcnh2 human etherhigher susceptibilityheterologous expressiongenetic screeningfirst mutationcomputer simulationsarrhythmogenic substratearrhythmogenic potentialsaction potentials>, resulting
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