After non-LAD PCI, LAD-hDPV and CFVR significantly decreased, whereas no significant change in LAD-bDPV was observed. (A) In a total cohort, the prevalence of LAD-CFVR of ≤2.0 after non-LAD PCI showed an increasing trend. (B) In the subgroup analysis of patients with functional less severe LAD stenosis (QFR>0.80), the prevalence of LAD-CFVR of ≤2.0 after non-LAD PCI was significantly increased. Abbreviations as in Fig 1.